Metaflumizone – a new ectoparasiticide for dogs and cats

• Main Authors: Lidia Chitimia, Cosoroaba I.
• Format: Article
• Language: English
• Published: Romanian National Association of the Veterinary Products Manufacturers 2007-12-01
• Series: Medicamentul Veterinar
• Subjects: metaflumizone; pyrazoline; ProMeris®
• Online Access: http://www.veterinarypharmacon.com/docs/405-ARTICOL%208%20LIDIA.pdf

Metaflumizone, carbanilohydrazide, was discovered by Nihon Nohyaku in the early 1990’s and belongs to the new class of semicarbazone insecticides. Metaflumizone is derived from the pyrazoline chemistry and acts by the voltage-dependent sodium channels in insects binding. Metaflumizone produces a relaxed paralysis in a broad range of important pest insects. It has a potent activity against fleas and formulated in association with amitraz provide high control of fleas, ticks and mites on dogs. It is marketed as ProMeris® for ectoparasiticide use in cats or ProMeris/ProMeris Duo® for dogs. Applications of metaflumizone - spot-on - provided at least 6-8 weeks control of fleas and metaflumizone plus amitraz combination provided at least 3-6 weeks of ticks. Topical applications reduced the pruritic behaviour and clinical signs associated with Flea Allergic Dermatitis in cats and dogs.