Improved anti-cancer effect of epidermal growth factor-gold nanoparticle conjugates by protein orientation through site-specific mutagenesis

Improved anti-cancer effect of epidermal growth factor-gold nanoparticle conjugates by protein orientation through site-specific mutagenesis

Epidermal growth factor (EGF)-nanoparticle conjugates have the potential for cancer therapeutics due to the unique cytotoxic activity in cancer cells with EGF receptor (EGFR) overexpression. To gain its maximum activity, the EGF molecule should be immobilized on the nanoparticle surface in a defined...

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Bibliographic Details
Main Authors: Aiwen Zhang, Jun Nakanishi
Format: Article
Language:English
Published: Taylor & Francis Group 2021-12-01
Series:Science and Technology of Advanced Materials
Subjects:
nanomedicine
egf-nanoparticle conjugates
protein orientation
phosphorylation signaling
growth inhibition
binding activity
Online Access:http://dx.doi.org/10.1080/14686996.2021.1944783

Internet

http://dx.doi.org/10.1080/14686996.2021.1944783

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