Atria Selective Prolongation by NIP-142, an Antiarrhythmic Agent, of Refractory Period and Action Potential Duration in Guinea Pig Myocardium

Atria Selective Prolongation by NIP-142, an Antiarrhythmic Agent, of Refractory Period and Action Potential Duration in Guinea Pig Myocardium

NIP-142 is a novel benzopyran compound that was shown to prolong the atrial effective refractory period and terminate experimental atrial fibrillation in the dog. In the present study, we examined the effects of NIP-142 on isolated guinea pig myocardium and on the G-protein-coupled inwardly rectifyi...

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Bibliographic Details
Main Authors: Tomoyuki Matsuda, Kentaro Takeda, Mie Ito, Reiko Yamagishi, Miku Tamura, Hideki Nakamura, Noriko Tsuruoka, Tomoaki Saito, Haruko Masumiya, Takeshi Suzuki, Naoko Iida-Tanaka, Maho Itokawa-Matsuda, Toru Yamashita, Nobutomo Tsuruzoe, Hikaru Tanaka, Koki Shigenobu
Format: Article
Language:English
Published: Elsevier 2005-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319322121

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