Significantly Reduced Salivary Nitric Oxide Synthesis in Patients with Parkinson’s Disease

• Main Authors: Jasminko Huskić, Alma Paperniku, Azra Husić, Faruk Alendar, Nedžad Mulabegović
• Format: Article
• Language: English
• Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2005-08-01
• Series: Bosnian Journal of Basic Medical Sciences
• Subjects: nitric oxide; Parkinson’s disease; saliva
• Online Access: http://bjbms.org/ojs/index.php/bjbms/article/view/3277

In order to study concentration of nitric oxide (NO) in the saliva of patients with Parkinson’s disease (PD), we measured the concentration of its stable metabolite nitrite (NO2-) in the saliva of these patients and healthy subjects. We analyzed saliva flow rate and salivary NO concentrations in 16 subjects with Parkinson’s disease and in 16 healthy subjects. Concentration of nitrite was determined by colorimetric method using Griess reaction. Saliva flow rate was significantly lower in patients with Parkinson’s disease (0,2±0,03 mL/min; X±SEM) than in healthy subjects. Salivary NO2-concen-tration was significantly lower (5,0210,64) than in healthy individuals (22,3911,24; p<0,0001).