Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer’s disease

Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer’s disease

Abstract Background Discrepant and often contradictory results have accumulated regarding the antidepressant and pro-cognitive effects of serotonin transporter (SERT) antagonists in Alzheimer’s disease. Methods To address the discrepancy, we measured the activity and density of SERT in the neocortex...

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Bibliographic Details
Main Authors: Athanasios Metaxas, Marco Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne M. Landau, Bente Finsen
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
APP swe /PS1 dE9
Amyloid-beta
SSRIs
Serotonin transporter
DASB
Online Access:http://link.springer.com/article/10.1186/s13195-019-0491-2

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