AC-93253 iodide, a novel Src inhibitor, suppresses NSCLC progression by modulating multiple Src-related signaling pathways

Abstract Background The tyrosine kinase Src is involved in the progression of many cancers. Moreover, inhibiting Src activity has been shown to obstruct several signaling pathways regulated by the EGFR. Thus, Src is a valuable target molecule in drug development. The purpose of this study was to ide...

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Bibliographic Details
Main Authors: Yi-Hua Lai, Sih-Yin Lin, Yu-Shan Wu, Huei-Wen Chen, Jeremy J. W. Chen
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Journal of Hematology & Oncology
Subjects:
Src
Online Access:http://link.springer.com/article/10.1186/s13045-017-0539-3