TGFβ Imprinting During Activation Promotes Natural Killer Cell Cytokine Hypersecretion

TGFβ Imprinting During Activation Promotes Natural Killer Cell Cytokine Hypersecretion

Transforming growth factor-beta (TGFβ) is a potent immunosuppressive cytokine that inhibits the anti-tumor responses of NK cells and T cells. However, the stimulation of natural killer (NK) cells with pro-inflammatory cytokines decreases NK cell sensitivity to TGFβ. Herein, we soug...

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Bibliographic Details
Main Authors: Jennifer A. Foltz, Jena E. Moseman, Aarohi Thakkar, Nitin Chakravarti, Dean A. Lee
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Cancers
Subjects:
natural killer cells
TGFβ
IFNγ
cell therapy
IL-2
cytokines
immune therapy
tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/10/11/423

Internet

https://www.mdpi.com/2072-6694/10/11/423

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