Acute systemic LPS-exposure impairs perivascular CSF distribution in mice

Acute systemic LPS-exposure impairs perivascular CSF distribution in mice

Abstract Background The exchange of cerebrospinal (CSF) and interstitial fluid is believed to be vital for waste clearance in the brain. The sleep-dependent glymphatic system, which is comprised of perivascular flow of CSF and is largely dependent on arterial pulsatility and astrocytic aquaporin-4 (...

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Bibliographic Details
Main Authors: Oscar Manouchehrian, Marta Ramos, Sara Bachiller, Iben Lundgaard, Tomas Deierborg
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Neuroinflammation
Subjects:
LPS
CSF
Microglia
Glymphatic System
AQP4
Inflammation
Online Access:https://doi.org/10.1186/s12974-021-02082-6

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