Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin

<p/> <p>Background</p> <p>The Ouabain and Adducin for Specific Intervention on Sodium in Hypertension (OASIS-HT) Trial was a phase-2 dose-finding study of rostafuroxin, a digitoxygenin derivative, which selectively antagonizes the effects of endogenous ouabain (EO) on Na<s...

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Main Authors: Citterio Lorena, Lanzani Chiara, Souček Miroslav, Nikitin Yuri, Milyagin Viktor, Manunta Paolo, Januszewicz Andrzej, Glorioso Nicola, Dłużniewski Mirosław, de Leeuw Peter W, Espositi Ezio, Barton John, Bacchieri Antonella, Stolarz-Skrzypek Katarzyna, Thijs Lutgarde, Staessen Jan A, Timio Mario, Tykarski Andrzej, Ferrari Patrizia, Valentini Giovanni, Kawecka-Jaszcz Kalina, Bianchi Giuseppe
Format: Article
Language:English
Published: BMC 2011-01-01
Series:Trials
Online Access:http://www.trialsjournal.com/content/12/1/13