The Range of Uncertainty: A Tool for Efficiently Addressing Result Variability around Clinical Decision Points for Hepatitis C Response-guided Therapy

The Range of Uncertainty: A Tool for Efficiently Addressing Result Variability around Clinical Decision Points for Hepatitis C Response-guided Therapy

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Despite efforts to standardize molecular diagnostic tests, performance differences are not rare. Laboratories are challenged in situations where treatment rules have been established using a reference assay that is different from the assays being used in daily practice. Assessing the viral load stat...

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Bibliographic Details
Main Authors: Paul Jülicher, Jens Dhein
Format: Article
Language:English
Published: SAGE Publishing 2014-01-01
Series:Biomarker Insights
Online Access:https://doi.org/10.4137/BMI.S14481
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spelling doaj-feaaa6cbbf9f499a946c640ba8d377ae2020-11-25T03:09:24ZengSAGE PublishingBiomarker Insights1177-27192014-01-01910.4137/BMI.S14481The Range of Uncertainty: A Tool for Efficiently Addressing Result Variability around Clinical Decision Points for Hepatitis C Response-guided TherapyPaul Jülicher0Jens Dhein1Abbott GmbH and Co KG, Wiesbaden, Germany.Abbott GmbH and Co KG, Wiesbaden, Germany.Despite efforts to standardize molecular diagnostic tests, performance differences are not rare. Laboratories are challenged in situations where treatment rules have been established using a reference assay that is different from the assays being used in daily practice. Assessing the viral load status of patients with chronic hepatitis C under modern triple therapy is a recognized example. We demonstrate the use of the range of uncertainty as an easy and efficient tool that can provide information on the certainty of a test result's interpretation in the context of making hepatitis C virus treatment decisions.https://doi.org/10.4137/BMI.S14481
collection DOAJ
language English
format Article
sources DOAJ
author Paul Jülicher
Jens Dhein
spellingShingle Paul Jülicher
Jens Dhein
The Range of Uncertainty: A Tool for Efficiently Addressing Result Variability around Clinical Decision Points for Hepatitis C Response-guided Therapy
Biomarker Insights
author_facet Paul Jülicher
Jens Dhein
author_sort Paul Jülicher
title The Range of Uncertainty: A Tool for Efficiently Addressing Result Variability around Clinical Decision Points for Hepatitis C Response-guided Therapy
title_short The Range of Uncertainty: A Tool for Efficiently Addressing Result Variability around Clinical Decision Points for Hepatitis C Response-guided Therapy
title_full The Range of Uncertainty: A Tool for Efficiently Addressing Result Variability around Clinical Decision Points for Hepatitis C Response-guided Therapy
title_fullStr The Range of Uncertainty: A Tool for Efficiently Addressing Result Variability around Clinical Decision Points for Hepatitis C Response-guided Therapy
title_full_unstemmed The Range of Uncertainty: A Tool for Efficiently Addressing Result Variability around Clinical Decision Points for Hepatitis C Response-guided Therapy
title_sort range of uncertainty: a tool for efficiently addressing result variability around clinical decision points for hepatitis c response-guided therapy
publisher SAGE Publishing
series Biomarker Insights
issn 1177-2719
publishDate 2014-01-01
description Despite efforts to standardize molecular diagnostic tests, performance differences are not rare. Laboratories are challenged in situations where treatment rules have been established using a reference assay that is different from the assays being used in daily practice. Assessing the viral load status of patients with chronic hepatitis C under modern triple therapy is a recognized example. We demonstrate the use of the range of uncertainty as an easy and efficient tool that can provide information on the certainty of a test result's interpretation in the context of making hepatitis C virus treatment decisions.
url https://doi.org/10.4137/BMI.S14481
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AT pauljulicher rangeofuncertaintyatoolforefficientlyaddressingresultvariabilityaroundclinicaldecisionpointsforhepatitiscresponseguidedtherapy
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