Resistance to thyrotropin: familial case report

Resistance to thyrotropin: familial case report

Two female dizygotic twins with subclinical primary hypothyroidism due to homozygous p.R450H mutation in TSHR gene are presented. A 5-year follow-up in both cases showed no progression of thyroid dysfunction. Indications for levothyroxine replacement in subclinical hypothyroidism are discussed.

Bibliographic Details
Main Authors: Mariya Aleksandrovna Osipovskaya, Alexey Vasil'evich Kiyaev, Nina Alekseevna Makretskaya, Evgeny Viktorovich Vasiliev, Anatoly Nikolaevich Tiulpakov
Format: Article
Language:Russian
Published: Endocrinology Research Centre 2016-02-01
Series:Клиническая и экспериментальная тиреоидология
Subjects:
subclinical hypothyroidism
resistance to thyrotropin
tshr
children
Online Access:https://cet-endojournals.ru/ket/article/viewFile/7699/5652
id doaj-fea80bbed7974e1eb6d93b9cd0cedc5e
record_format Article
spelling doaj-fea80bbed7974e1eb6d93b9cd0cedc5e2021-06-02T19:26:30ZrusEndocrinology Research CentreКлиническая и экспериментальная тиреоидология1995-54722310-37872016-02-01114363910.14341/ket2015436-397340Resistance to thyrotropin: familial case reportMariya Aleksandrovna Osipovskaya0Alexey Vasil'evich Kiyaev1Nina Alekseevna Makretskaya2Evgeny Viktorovich Vasiliev3Anatoly Nikolaevich Tiulpakov4Ural State Medical UniversityUral State Medical UniversityEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreTwo female dizygotic twins with subclinical primary hypothyroidism due to homozygous p.R450H mutation in TSHR gene are presented. A 5-year follow-up in both cases showed no progression of thyroid dysfunction. Indications for levothyroxine replacement in subclinical hypothyroidism are discussed.https://cet-endojournals.ru/ket/article/viewFile/7699/5652subclinical hypothyroidismresistance to thyrotropintshrchildren
collection DOAJ
language Russian
format Article
sources DOAJ
author Mariya Aleksandrovna Osipovskaya
Alexey Vasil'evich Kiyaev
Nina Alekseevna Makretskaya
Evgeny Viktorovich Vasiliev
Anatoly Nikolaevich Tiulpakov
spellingShingle Mariya Aleksandrovna Osipovskaya
Alexey Vasil'evich Kiyaev
Nina Alekseevna Makretskaya
Evgeny Viktorovich Vasiliev
Anatoly Nikolaevich Tiulpakov
Resistance to thyrotropin: familial case report
Клиническая и экспериментальная тиреоидология
subclinical hypothyroidism
resistance to thyrotropin
tshr
children
author_facet Mariya Aleksandrovna Osipovskaya
Alexey Vasil'evich Kiyaev
Nina Alekseevna Makretskaya
Evgeny Viktorovich Vasiliev
Anatoly Nikolaevich Tiulpakov
author_sort Mariya Aleksandrovna Osipovskaya
title Resistance to thyrotropin: familial case report
title_short Resistance to thyrotropin: familial case report
title_full Resistance to thyrotropin: familial case report
title_fullStr Resistance to thyrotropin: familial case report
title_full_unstemmed Resistance to thyrotropin: familial case report
title_sort resistance to thyrotropin: familial case report
publisher Endocrinology Research Centre
series Клиническая и экспериментальная тиреоидология
issn 1995-5472
2310-3787
publishDate 2016-02-01
description Two female dizygotic twins with subclinical primary hypothyroidism due to homozygous p.R450H mutation in TSHR gene are presented. A 5-year follow-up in both cases showed no progression of thyroid dysfunction. Indications for levothyroxine replacement in subclinical hypothyroidism are discussed.
topic subclinical hypothyroidism
resistance to thyrotropin
tshr
children
url https://cet-endojournals.ru/ket/article/viewFile/7699/5652
work_keys_str_mv AT mariyaaleksandrovnaosipovskaya resistancetothyrotropinfamilialcasereport
AT alexeyvasilevichkiyaev resistancetothyrotropinfamilialcasereport
AT ninaalekseevnamakretskaya resistancetothyrotropinfamilialcasereport
AT evgenyviktorovichvasiliev resistancetothyrotropinfamilialcasereport
AT anatolynikolaevichtiulpakov resistancetothyrotropinfamilialcasereport
_version_ 1721401674193436672

Similar Items