Resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicity.

Resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicity.

It has been recently suggested that resveratrol can be effective in slowing down Alzheimer's disease (AD) development. As reported in many biochemical studies, resveratrol seems to exert its neuro-protective role through inhibition of β-amyloid aggregation (Aβ), by scavenging oxidants and exert...

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Main Authors: Alberto Granzotto, Paolo Zatta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3124535?pdf=render
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spelling doaj-fe94cf77a5ab4a4ab66c5775dc5817c92020-11-25T02:42:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0166e2156510.1371/journal.pone.0021565Resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicity.Alberto GranzottoPaolo ZattaIt has been recently suggested that resveratrol can be effective in slowing down Alzheimer's disease (AD) development. As reported in many biochemical studies, resveratrol seems to exert its neuro-protective role through inhibition of β-amyloid aggregation (Aβ), by scavenging oxidants and exerting anti-inflammatory activities. In this paper, we demonstrate that resveratrol is cytoprotective in human neuroblastoma cells exposed to Aβ and or to Aβ-metal complex. Our findings suggest that resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties.http://europepmc.org/articles/PMC3124535?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Alberto Granzotto
Paolo Zatta
spellingShingle Alberto Granzotto
Paolo Zatta
Resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicity.
PLoS ONE
author_facet Alberto Granzotto
Paolo Zatta
author_sort Alberto Granzotto
title Resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicity.
title_short Resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicity.
title_full Resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicity.
title_fullStr Resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicity.
title_full_unstemmed Resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicity.
title_sort resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against aβ and aβ-metal complexes toxicity.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2011-01-01
description It has been recently suggested that resveratrol can be effective in slowing down Alzheimer's disease (AD) development. As reported in many biochemical studies, resveratrol seems to exert its neuro-protective role through inhibition of β-amyloid aggregation (Aβ), by scavenging oxidants and exerting anti-inflammatory activities. In this paper, we demonstrate that resveratrol is cytoprotective in human neuroblastoma cells exposed to Aβ and or to Aβ-metal complex. Our findings suggest that resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties.
url http://europepmc.org/articles/PMC3124535?pdf=render
work_keys_str_mv AT albertogranzotto resveratrolactsnotthroughantiaggregativepathwaysbutmainlyviaitsscavengingpropertiesagainstabandabmetalcomplexestoxicity
AT paolozatta resveratrolactsnotthroughantiaggregativepathwaysbutmainlyviaitsscavengingpropertiesagainstabandabmetalcomplexestoxicity
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