Integration of metabolomics and transcriptomics reveals short-chain chlorinated paraffin-induced hepatotoxicity in male Sprague-Dawley rat

Background: Short-chain chlorinated paraffins (SCCPs) used in various industrial applications have been listed as new POPs. Previous studies based on high-dose exposures indicate their hepatotoxicity. However, their mechanisms of toxicity or adverse outcome pathways and health risks remain largely u...

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Bibliographic Details
Main Authors: Ningbo Geng, Xiaoqian Ren, Yufeng Gong, Haijun Zhang, Feidi Wang, Liguo Xing, Rong Cao, Jiazhi Xu, Yuan Gao, John P. Giesy, Jiping Chen
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Environment International
Online Access:http://www.sciencedirect.com/science/article/pii/S016041201932642X