Asymmetric biomimetic transamination of α-keto amides to peptides

Asymmetric biomimetic transamination of α-keto amides to peptides

Asymmetric transamination of α-keto amides could provide an efficient strategy to synthesise peptides, but has not been well developed yet. Here, the authors design chiral pyridoxamine catalyst and realize the asymmetric biomimetic transamination of α-keto amides, providing access to various peptide...

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Main Authors: Weiqi Cai, Xuelong Qiao, Hao Zhang, Bo Li, Jianhua Guo, Liangliang Zhang, Wen-Wen Chen, Baoguo Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25449-y
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spelling doaj-fe90a4183f1e4373aaebb49c05c7f7192021-09-05T11:44:18ZengNature Publishing GroupNature Communications2041-17232021-08-011211910.1038/s41467-021-25449-yAsymmetric biomimetic transamination of α-keto amides to peptidesWeiqi Cai0Xuelong Qiao1Hao Zhang2Bo Li3Jianhua Guo4Liangliang Zhang5Wen-Wen Chen6Baoguo Zhao7The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal UniversityThe Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal UniversityThe Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal UniversityThe Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal UniversityThe Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal UniversityThe Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal UniversityThe Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal UniversityThe Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal UniversityAsymmetric transamination of α-keto amides could provide an efficient strategy to synthesise peptides, but has not been well developed yet. Here, the authors design chiral pyridoxamine catalyst and realize the asymmetric biomimetic transamination of α-keto amides, providing access to various peptides with excellent enantiopurities.https://doi.org/10.1038/s41467-021-25449-y
collection DOAJ
language English
format Article
sources DOAJ
author Weiqi Cai
Xuelong Qiao
Hao Zhang
Bo Li
Jianhua Guo
Liangliang Zhang
Wen-Wen Chen
Baoguo Zhao
spellingShingle Weiqi Cai
Xuelong Qiao
Hao Zhang
Bo Li
Jianhua Guo
Liangliang Zhang
Wen-Wen Chen
Baoguo Zhao
Asymmetric biomimetic transamination of α-keto amides to peptides
Nature Communications
author_facet Weiqi Cai
Xuelong Qiao
Hao Zhang
Bo Li
Jianhua Guo
Liangliang Zhang
Wen-Wen Chen
Baoguo Zhao
author_sort Weiqi Cai
title Asymmetric biomimetic transamination of α-keto amides to peptides
title_short Asymmetric biomimetic transamination of α-keto amides to peptides
title_full Asymmetric biomimetic transamination of α-keto amides to peptides
title_fullStr Asymmetric biomimetic transamination of α-keto amides to peptides
title_full_unstemmed Asymmetric biomimetic transamination of α-keto amides to peptides
title_sort asymmetric biomimetic transamination of α-keto amides to peptides
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-08-01
description Asymmetric transamination of α-keto amides could provide an efficient strategy to synthesise peptides, but has not been well developed yet. Here, the authors design chiral pyridoxamine catalyst and realize the asymmetric biomimetic transamination of α-keto amides, providing access to various peptides with excellent enantiopurities.
url https://doi.org/10.1038/s41467-021-25449-y
work_keys_str_mv AT weiqicai asymmetricbiomimetictransaminationofaketoamidestopeptides
AT xuelongqiao asymmetricbiomimetictransaminationofaketoamidestopeptides
AT haozhang asymmetricbiomimetictransaminationofaketoamidestopeptides
AT boli asymmetricbiomimetictransaminationofaketoamidestopeptides
AT jianhuaguo asymmetricbiomimetictransaminationofaketoamidestopeptides
AT liangliangzhang asymmetricbiomimetictransaminationofaketoamidestopeptides
AT wenwenchen asymmetricbiomimetictransaminationofaketoamidestopeptides
AT baoguozhao asymmetricbiomimetictransaminationofaketoamidestopeptides
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