| Summary: | Background: Background data on the allergic constitutions of a general population of Japanese children may provide important information regarding environmental factors that contribute to the increased incidence of allergic diseases and suggest clues for their prevention.
Methods: Serum samples were obtained from a general population of 3-year-old children (612 samples) in the Kanto area and Asahikawa city. The serum levels of total and specific IgE antibodies against food allergens (egg white, milk, soybean, wheat), indoor airborne allergens (house dust, mite, cat dandruff), and outdoor airborne allergens (Japanese cedar or white birch pollen allergens) were determined and analyzed, along with the results of a questionnaire regarding medical history, and allergy-related subjective symptoms.
Results: The mean total IgE level of all subjects was 34.7 IU/ml, while that for the Kanto and Asahikawa areas was 44.7 and 22.5 IU/ml, respectively. Twenty six percent of the 612 children were judged positive for indoor airborne allergen-specific IgE, and 6.7% were positive for food allergen-specific IgE. Cedar allergen-specific IgE was detected in 15.6% of the children living in the Kanto area. The total IgE level was strongly correlated with the number of allergens to which the child was sensitized.
Conclusions: A relatively large number (28.4%) of 3-year-old children possessed allergen-specific IgE antibodies. The basic data obtained in the general population in these two areas of Japan will be valuable for further evaluations of environmental influences on allergic disease.
|
|---|
