Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data

Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data

Hypoxia adversely affects the pulmonary circulation of mammals, including vasoconstriction leading to elevated pulmonary arterial pressures. The clinical importance of changes in the structure and function of the large, elastic pulmonary arteries is gaining increased attention, particularly regardin...

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Bibliographic Details
Main Authors: Edward P. Manning, Abhay B. Ramachandra, Jonas C. Schupp, Cristina Cavinato, Micha Sam Brickman Raredon, Thomas Bärnthaler, Carlos Cosme, Inderjit Singh, George Tellides, Naftali Kaminski, Jay D. Humphrey
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
pulmonary artery
hypoxia
mouse
vascular
remodeling
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.726253/full

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