AlGaN/GaN High Electron Mobility Transistor-Based Biosensor for the Detection of C-Reactive Protein
In this paper, we propose an AlGaN/GaN high electron mobility transistor (HEMT)-based biosensor for the detection of C-reactive protein (CRP) using a null-balancing circuit. A null-balancing circuit was used to measure the output voltage of the sensor directly. The output voltage of the proposed bi...
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MDPI AG
2015-07-01
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| Series: | Sensors |
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| Online Access: | http://www.mdpi.com/1424-8220/15/8/18416 |
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doaj-fe83304692c44a1bb0be225883c479b22020-11-24T22:01:01ZengMDPI AGSensors1424-82202015-07-01158184161842610.3390/s150818416s150818416AlGaN/GaN High Electron Mobility Transistor-Based Biosensor for the Detection of C-Reactive ProteinHee Ho Lee0Myunghan Bae1Sung-Hyun Jo2Jang-Kyoo Shin3Dong Hyeok Son4Chul-Ho Won5Hyun-Min Jeong6Jung-Hee Lee7Shin-Won Kang8School of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, KoreaSchool of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, KoreaSchool of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, KoreaSchool of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, KoreaSchool of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, KoreaSchool of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, KoreaSchool of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, KoreaSchool of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, KoreaSchool of Electronics Engineering, Kyunpook National University, 80 Daehakro, Buk-gu, Daegu 702-701, KoreaIn this paper, we propose an AlGaN/GaN high electron mobility transistor (HEMT)-based biosensor for the detection of C-reactive protein (CRP) using a null-balancing circuit. A null-balancing circuit was used to measure the output voltage of the sensor directly. The output voltage of the proposed biosensor was varied by antigen-antibody interactions on the gate surface due to CRP charges. The AlGaN/GaN HFET-based biosensor with null-balancing circuit applied shows that CRP can be detected in a wide range of concentrations, varying from 10 ng/mL to 1000 ng/mL. X-ray photoelectron spectroscopy was carried out to verify the immobilization of self-assembled monolayer with Au on the gated region.http://www.mdpi.com/1424-8220/15/8/18416AlGaN/GaNHEMTCRPbiosensornull-balancing circuit |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hee Ho Lee Myunghan Bae Sung-Hyun Jo Jang-Kyoo Shin Dong Hyeok Son Chul-Ho Won Hyun-Min Jeong Jung-Hee Lee Shin-Won Kang |
| spellingShingle |
Hee Ho Lee Myunghan Bae Sung-Hyun Jo Jang-Kyoo Shin Dong Hyeok Son Chul-Ho Won Hyun-Min Jeong Jung-Hee Lee Shin-Won Kang AlGaN/GaN High Electron Mobility Transistor-Based Biosensor for the Detection of C-Reactive Protein Sensors AlGaN/GaN HEMT CRP biosensor null-balancing circuit |
| author_facet |
Hee Ho Lee Myunghan Bae Sung-Hyun Jo Jang-Kyoo Shin Dong Hyeok Son Chul-Ho Won Hyun-Min Jeong Jung-Hee Lee Shin-Won Kang |
| author_sort |
Hee Ho Lee |
| title |
AlGaN/GaN High Electron Mobility Transistor-Based Biosensor for the Detection of C-Reactive Protein |
| title_short |
AlGaN/GaN High Electron Mobility Transistor-Based Biosensor for the Detection of C-Reactive Protein |
| title_full |
AlGaN/GaN High Electron Mobility Transistor-Based Biosensor for the Detection of C-Reactive Protein |
| title_fullStr |
AlGaN/GaN High Electron Mobility Transistor-Based Biosensor for the Detection of C-Reactive Protein |
| title_full_unstemmed |
AlGaN/GaN High Electron Mobility Transistor-Based Biosensor for the Detection of C-Reactive Protein |
| title_sort |
algan/gan high electron mobility transistor-based biosensor for the detection of c-reactive protein |
| publisher |
MDPI AG |
| series |
Sensors |
| issn |
1424-8220 |
| publishDate |
2015-07-01 |
| description |
In this paper, we propose an AlGaN/GaN high electron mobility transistor (HEMT)-based biosensor for the detection of C-reactive protein (CRP) using a null-balancing circuit. A null-balancing circuit was used to measure the output voltage of the sensor directly. The output voltage of the proposed biosensor was varied by antigen-antibody interactions on the gate surface due to CRP charges. The AlGaN/GaN HFET-based biosensor with null-balancing circuit applied shows that CRP can be detected in a wide range of concentrations, varying from 10 ng/mL to 1000 ng/mL. X-ray photoelectron spectroscopy was carried out to verify the immobilization of self-assembled monolayer with Au on the gated region. |
| topic |
AlGaN/GaN HEMT CRP biosensor null-balancing circuit |
| url |
http://www.mdpi.com/1424-8220/15/8/18416 |
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