Immunogenic lipid markers of atherosclerosis in type 2 diabetic patients on program haemodialysis

• Main Authors: T V Archakova, L V Nedosugova, N A Nikitina, A A Melnichenko, I A Sobenin
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2018-10-01
• Series: Терапевтический архив
• Subjects: type 2 diabetes mellitus; program hemodialysis; atherosclerosis; modified low density lipoprotein; lipoprotein-containing circulating immune complexes
• Online Access: https://ter-arkhiv.ru/0040-3660/article/viewFile/32850/pdf

Aim. Determination of desialized apolipoprotein-B-100 (apoB-100) and lipoprotein-containing circulating immune complexes in patients with chronic kidney disease (CKD) in program hemodialysis with type 2 diabetes mellitus. Materials and methods. We examined 81 patients with CKD (50 men / 31 women) treated with program hemodialysis, of which 36 (17/19) with type 2 diabetes mellitus, 45 (33/12) non-diabetic patients. The levels of total cholesterol, triglycerides and desialylated apoB-100 in blood plasma and lipoprotein-containing circulating immune complexes. A color duplex scan of brachiocephalic arteries was used to assess the extent of development of atherosclerosis with the determination of the thickness of the intima-medial complex. Results and discussion. Patients with diabetes had high values of total cholesterol, triglycerides (p