Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection

Combining diagnosis with therapy, magnetic iron oxide nanoparticles (INOPs) act as an important vehicle for drug delivery. However, poor biocompatibility of INOPs limits their application. To improve the shortcomings, various surface modifications have been developed, including small molecules coati...

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Main Authors:	Yanyue Wu, Zhiguo Lu, Yan Li, Jun Yang, Xin Zhang
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Series:	Nanomaterials
Subjects:	theranostics iron oxide magnetic nanoparticles blood-brain barrier surface coating target therapy
Online Access:	https://www.mdpi.com/2079-4991/10/8/1441

id	doaj-fe7a7bee4c6145c8b3809d912b42f6c0
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spelling	doaj-fe7a7bee4c6145c8b3809d912b42f6c02020-11-25T03:29:25ZengMDPI AGNanomaterials2079-49912020-07-01101441144110.3390/nano10081441Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and ProspectionYanyue Wu0Zhiguo Lu1Yan Li2Jun Yang3Xin Zhang4National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaNational Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaNational Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaNational Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaNational Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaCombining diagnosis with therapy, magnetic iron oxide nanoparticles (INOPs) act as an important vehicle for drug delivery. However, poor biocompatibility of INOPs limits their application. To improve the shortcomings, various surface modifications have been developed, including small molecules coatings, polymers coatings, lipid coatings and lipopolymer coatings. These surface modifications facilitate iron nanoparticles to cross the blood-brain-barrier, which is essential for diagnosis and treatments of brain diseases. Here we focus on the characteristics of different coated INOPs and their application in brain disease, particularly gliomas, Alzheimer’s disease (AD) and Parkinson’s disease (PD). Moreover, we summarize the current progress and expect to provide help for future researches.https://www.mdpi.com/2079-4991/10/8/1441theranosticsiron oxide magnetic nanoparticlesblood-brain barriersurface coatingtarget therapy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yanyue Wu Zhiguo Lu Yan Li Jun Yang Xin Zhang
spellingShingle	Yanyue Wu Zhiguo Lu Yan Li Jun Yang Xin Zhang Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection Nanomaterials theranostics iron oxide magnetic nanoparticles blood-brain barrier surface coating target therapy
author_facet	Yanyue Wu Zhiguo Lu Yan Li Jun Yang Xin Zhang
author_sort	Yanyue Wu
title	Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection
title_short	Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection
title_full	Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection
title_fullStr	Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection
title_full_unstemmed	Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection
title_sort	surface modification of iron oxide-based magnetic nanoparticles for cerebral theranostics: application and prospection
publisher	MDPI AG
series	Nanomaterials
issn	2079-4991
publishDate	2020-07-01
description	Combining diagnosis with therapy, magnetic iron oxide nanoparticles (INOPs) act as an important vehicle for drug delivery. However, poor biocompatibility of INOPs limits their application. To improve the shortcomings, various surface modifications have been developed, including small molecules coatings, polymers coatings, lipid coatings and lipopolymer coatings. These surface modifications facilitate iron nanoparticles to cross the blood-brain-barrier, which is essential for diagnosis and treatments of brain diseases. Here we focus on the characteristics of different coated INOPs and their application in brain disease, particularly gliomas, Alzheimer’s disease (AD) and Parkinson’s disease (PD). Moreover, we summarize the current progress and expect to provide help for future researches.
topic	theranostics iron oxide magnetic nanoparticles blood-brain barrier surface coating target therapy
url	https://www.mdpi.com/2079-4991/10/8/1441
work_keys_str_mv	AT yanyuewu surfacemodificationofironoxidebasedmagneticnanoparticlesforcerebraltheranosticsapplicationandprospection AT zhiguolu surfacemodificationofironoxidebasedmagneticnanoparticlesforcerebraltheranosticsapplicationandprospection AT yanli surfacemodificationofironoxidebasedmagneticnanoparticlesforcerebraltheranosticsapplicationandprospection AT junyang surfacemodificationofironoxidebasedmagneticnanoparticlesforcerebraltheranosticsapplicationandprospection AT xinzhang surfacemodificationofironoxidebasedmagneticnanoparticlesforcerebraltheranosticsapplicationandprospection
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Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection

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