Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity

Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity

Both inhibitory and excitatory input development are shaped by activity, but one may be dependent on the other. Here, the authors examine plasticity of inhibitory inputs in vivo, as well as behavioral consequences in tadpoles where excitatory transmission has been impaired.

Bibliographic Details
Main Authors: Hai-yan He, Wanhua Shen, Lijun Zheng, Xia Guo, Hollis T. Cline
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05125-4
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spelling doaj-fe7125f9a83347c9871914ef2010d97a2021-05-11T10:21:51ZengNature Publishing GroupNature Communications2041-17232018-07-019111410.1038/s41467-018-05125-4Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticityHai-yan He0Wanhua Shen1Lijun Zheng2Xia Guo3Hollis T. Cline4The Dorris Neuroscience Center, Department of Neuroscience, The Scripps Research InstituteZhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal UniversityZhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal UniversityZhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal UniversityThe Dorris Neuroscience Center, Department of Neuroscience, The Scripps Research InstituteBoth inhibitory and excitatory input development are shaped by activity, but one may be dependent on the other. Here, the authors examine plasticity of inhibitory inputs in vivo, as well as behavioral consequences in tadpoles where excitatory transmission has been impaired.https://doi.org/10.1038/s41467-018-05125-4
collection DOAJ
language English
format Article
sources DOAJ
author Hai-yan He
Wanhua Shen
Lijun Zheng
Xia Guo
Hollis T. Cline
spellingShingle Hai-yan He
Wanhua Shen
Lijun Zheng
Xia Guo
Hollis T. Cline
Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity
Nature Communications
author_facet Hai-yan He
Wanhua Shen
Lijun Zheng
Xia Guo
Hollis T. Cline
author_sort Hai-yan He
title Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity
title_short Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity
title_full Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity
title_fullStr Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity
title_full_unstemmed Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity
title_sort excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-07-01
description Both inhibitory and excitatory input development are shaped by activity, but one may be dependent on the other. Here, the authors examine plasticity of inhibitory inputs in vivo, as well as behavioral consequences in tadpoles where excitatory transmission has been impaired.
url https://doi.org/10.1038/s41467-018-05125-4
work_keys_str_mv AT haiyanhe excitatorysynapticdysfunctioncellautonomouslydecreasesinhibitoryinputsanddisruptsstructuralandfunctionalplasticity
AT wanhuashen excitatorysynapticdysfunctioncellautonomouslydecreasesinhibitoryinputsanddisruptsstructuralandfunctionalplasticity
AT lijunzheng excitatorysynapticdysfunctioncellautonomouslydecreasesinhibitoryinputsanddisruptsstructuralandfunctionalplasticity
AT xiaguo excitatorysynapticdysfunctioncellautonomouslydecreasesinhibitoryinputsanddisruptsstructuralandfunctionalplasticity
AT hollistcline excitatorysynapticdysfunctioncellautonomouslydecreasesinhibitoryinputsanddisruptsstructuralandfunctionalplasticity
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