Polymorphism of Interleukin 1B May Modulate the Risk of Ischemic Stroke in Polish Patients

• Main Authors: Iwona Gorący, Mariusz Kaczmarczyk, Andrzej Ciechanowicz, Klaudyna Lewandowska, Paweł Jakubiszyn, Oksana Bodnar, Bartosz Kopijek, Andrzej Brodkiewicz, Lech Cyryłowski
• Format: Article
• Language: English
• Published: MDPI AG 2019-09-01
• Series: Medicina
• Subjects: <i>IL1B</i>; <i>IL1RN</i>; polymorphism; stroke; inflammation
• Online Access: https://www.mdpi.com/1010-660X/55/9/558

<i>Background and Objectives</i>: Inflammation plays a crucial role in the pathophysiology of ischemic stroke (IS). Interleukin-1B and interleukin-1 receptor antagonists are key factors in inflammatory processes. Aims: The aims of our study were to evaluate the relationship between genetic variation in interleukin-1B (<i>IL1B</i>) rs1143627 and interleukin-1 receptor antagonist (<i>IL1RN</i>) variable-number-tandem-repeats (VNTR), and overall IS and subtype prevalence rates. <i>Materials and Methods:</i> The analysis included 147 hospitalized Polish patients with IS diagnosed using conventional criteria. The control group consisted of 119 healthy subjects. Genotypes were determined by polymerase chain reaction. <i>Results:</i> A significant association between rs1143627 and stroke was found. The -31C <i>IL1B</i> polymorphism showed an association with overall IS, OR = 2.30 (1.36&#8722;3.87) <i>p</i> = 0.020. An association was also detected for LVI (large vessel infarction) subtypes of stroke. After risk factor adjustment (age, diabetes mellitus, dyslipidemia), the C allele was found to be an independent risk factor for LVI, OR = 1.99 (1.05&#8722;3.79) <i>p</i> = 0.036. Significant association was not observed between <i>IL1RN</i> alleles and IS. <i>Conclusions:</i> Our results suggest that the C allele of <i>IL1B</i> rs1143627 may be associated with susceptibility to overall IS and LVI subtypes of stroke in the Polish population.