KIR2DL5: an orphan inhibitory receptor displaying complex patterns of polymorphism and expression

KIR2DL5: an orphan inhibitory receptor displaying complex patterns of polymorphism and expression

A recently developed anti-KIR2DL5 (CD158f) antibody has demonstrated KIR2DL5 expression on the surface of NK and T lymphocytes, making it the last functional KIR identified in the human genome. KIR2DL5 belongs to an ancestral lineage of KIR with Ig-like domains of the D0-D2 type, of which KIR2DL4, a...

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Bibliographic Details
Main Authors: Elisa eCisneros, Manuela eMoraru, Natalia eGómez-Lozano, Miguel eLópez-Botet, Carlos eVilches
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-09-01
Series:Frontiers in Immunology
Subjects:
Transcription, Genetic
KIR
inhibitory receptors
gene polymorphism
human NK cells
NK cell receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00289/full

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