Preparation and Characterization of Water-Soluble Chitosan Nanoparticles as Protein Delivery System

Preparation and Characterization of Water-Soluble Chitosan Nanoparticles as Protein Delivery System

The objective of this study was to investigate the potential of water soluble chitosan as a carrier in the preparation of protein-loaded nanoparticles. Nanoparticles were prepared by ionotropic gelation of water-soluble chitosan (WSC) with sodium tripolyphosphate (TPP). Bovine serum albumin (BSA) wa...

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Main Authors: Hong-liang Zhang, Si-hui Wu, Yi Tao, Lin-quan Zang, Zheng-quan Su
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Journal of Nanomaterials
Online Access:http://dx.doi.org/10.1155/2010/898910
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spelling doaj-fe4286d0afc941f08b476e0248b6b82d2020-11-24T20:41:24ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292010-01-01201010.1155/2010/898910898910Preparation and Characterization of Water-Soluble Chitosan Nanoparticles as Protein Delivery SystemHong-liang Zhang0Si-hui Wu1Yi Tao2Lin-quan Zang3Zheng-quan Su4College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaCollege of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaCollege of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaCollege of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaCollege of Public Health, Guangdong Pharmaceutical University, Guangzhou 510240, ChinaThe objective of this study was to investigate the potential of water soluble chitosan as a carrier in the preparation of protein-loaded nanoparticles. Nanoparticles were prepared by ionotropic gelation of water-soluble chitosan (WSC) with sodium tripolyphosphate (TPP). Bovine serum albumin (BSA) was applied as a model drug. The size and morphology of the nanoparticles were investigated as a function of the preparation conditions. The particles were spherical in shape and had a smooth surface. The size range of the nanoparticles was between 100 and 400 nm. Result of the in vitro studies showed that the WSC nanoparticles enhance and prolong the intestinal absorption of BSA. These results also indicated that WSC nanoparticles were a potential protein delivery system.http://dx.doi.org/10.1155/2010/898910
collection DOAJ
language English
format Article
sources DOAJ
author Hong-liang Zhang
Si-hui Wu
Yi Tao
Lin-quan Zang
Zheng-quan Su
spellingShingle Hong-liang Zhang
Si-hui Wu
Yi Tao
Lin-quan Zang
Zheng-quan Su
Preparation and Characterization of Water-Soluble Chitosan Nanoparticles as Protein Delivery System
Journal of Nanomaterials
author_facet Hong-liang Zhang
Si-hui Wu
Yi Tao
Lin-quan Zang
Zheng-quan Su
author_sort Hong-liang Zhang
title Preparation and Characterization of Water-Soluble Chitosan Nanoparticles as Protein Delivery System
title_short Preparation and Characterization of Water-Soluble Chitosan Nanoparticles as Protein Delivery System
title_full Preparation and Characterization of Water-Soluble Chitosan Nanoparticles as Protein Delivery System
title_fullStr Preparation and Characterization of Water-Soluble Chitosan Nanoparticles as Protein Delivery System
title_full_unstemmed Preparation and Characterization of Water-Soluble Chitosan Nanoparticles as Protein Delivery System
title_sort preparation and characterization of water-soluble chitosan nanoparticles as protein delivery system
publisher Hindawi Limited
series Journal of Nanomaterials
issn 1687-4110
1687-4129
publishDate 2010-01-01
description The objective of this study was to investigate the potential of water soluble chitosan as a carrier in the preparation of protein-loaded nanoparticles. Nanoparticles were prepared by ionotropic gelation of water-soluble chitosan (WSC) with sodium tripolyphosphate (TPP). Bovine serum albumin (BSA) was applied as a model drug. The size and morphology of the nanoparticles were investigated as a function of the preparation conditions. The particles were spherical in shape and had a smooth surface. The size range of the nanoparticles was between 100 and 400 nm. Result of the in vitro studies showed that the WSC nanoparticles enhance and prolong the intestinal absorption of BSA. These results also indicated that WSC nanoparticles were a potential protein delivery system.
url http://dx.doi.org/10.1155/2010/898910
work_keys_str_mv AT hongliangzhang preparationandcharacterizationofwatersolublechitosannanoparticlesasproteindeliverysystem
AT sihuiwu preparationandcharacterizationofwatersolublechitosannanoparticlesasproteindeliverysystem
AT yitao preparationandcharacterizationofwatersolublechitosannanoparticlesasproteindeliverysystem
AT linquanzang preparationandcharacterizationofwatersolublechitosannanoparticlesasproteindeliverysystem
AT zhengquansu preparationandcharacterizationofwatersolublechitosannanoparticlesasproteindeliverysystem
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