A Meta-Analysis of Circulating Microvesicles in Patients with Myocardial Infarction

• Main Authors: Zhida Wang, Wang Cai, Shaolan Hu, Yufei Xia, Yao Wang, Qi Zhang, Liming Chen
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Cardiologia (SBC)
• Series: Arquivos Brasileiros de Cardiologia
• Subjects: Infarto do Miocárdio; Micropartículas Derivadas de Células; Anexina A5; Plaquetas; Leucócitos; Endotélio
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017005001305&lng=en&tlng=en

Abstract Background: Cell-derived microvesicles (MVs) are vesicles released from activated or apoptotic cells. However, the levels of MVs in myocardial infarction have been found inconsistent in researches. Objective: To assess the association between MVs and myocardial infarction by conducting a meta-analysis. Methods: A systematic literature search on PubMed, Embase, Cochran, Google Scholar electronic database was conducted. Comparison of the MVs levels between myocardial infarction patients and healthy persons were included in our study. Standard Mean Difference (SMD) and 95% confidence interval (CI) in groups were calculated and meta-analyzed. Results: 11 studies with a total of 436 participants were included. Compared with the health persons, AMVs [SMD = 3.65, 95% CI (1.03, 6.27)], PMVs [SMD = 2.88, 95% CI (1.82, 3.93),] and EMVs [SMD = 2.73, 95% CI (1.13, 4.34)], levels were higher in patients with myocardial infarction. However, LMVs levels [SMD = 0.73, 95% CI (-0.57, 2.03)] were not changed significantly in patients with myocardial infarction. Conclusions: AMVs, PMVs and EMVs might be potential biomarkers for myocardial infarction.