Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.

Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.

The placenta is the interface between maternal and fetal circulations, integrating maternal and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as secrete hormones. In turn, the placenta helps create the in utero environment and control fetal growth and development....

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Main Authors: Amanda Vlahos, Toby Mansell, Richard Saffery, Boris Novakovic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-08-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008236
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spelling doaj-fe33b8e44cf5440eb881332c0022e8a02021-04-21T13:48:25ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042019-08-01158e100823610.1371/journal.pgen.1008236Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.Amanda VlahosToby MansellRichard SafferyBoris NovakovicThe placenta is the interface between maternal and fetal circulations, integrating maternal and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as secrete hormones. In turn, the placenta helps create the in utero environment and control fetal growth and development. The unique epigenetic profile of the human placenta likely reflects its early developmental separation from the fetus proper and its role in mediating maternal-fetal exchange that leaves it open to a range of exogenous exposures in the maternal circulation. In this review, we cover recent advances in DNA methylation in the context of placental function and development, as well as the interaction between the pregnancy and the environment.https://doi.org/10.1371/journal.pgen.1008236
collection DOAJ
language English
format Article
sources DOAJ
author Amanda Vlahos
Toby Mansell
Richard Saffery
Boris Novakovic
spellingShingle Amanda Vlahos
Toby Mansell
Richard Saffery
Boris Novakovic
Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.
PLoS Genetics
author_facet Amanda Vlahos
Toby Mansell
Richard Saffery
Boris Novakovic
author_sort Amanda Vlahos
title Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.
title_short Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.
title_full Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.
title_fullStr Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.
title_full_unstemmed Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.
title_sort human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.
publisher Public Library of Science (PLoS)
series PLoS Genetics
issn 1553-7390
1553-7404
publishDate 2019-08-01
description The placenta is the interface between maternal and fetal circulations, integrating maternal and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as secrete hormones. In turn, the placenta helps create the in utero environment and control fetal growth and development. The unique epigenetic profile of the human placenta likely reflects its early developmental separation from the fetus proper and its role in mediating maternal-fetal exchange that leaves it open to a range of exogenous exposures in the maternal circulation. In this review, we cover recent advances in DNA methylation in the context of placental function and development, as well as the interaction between the pregnancy and the environment.
url https://doi.org/10.1371/journal.pgen.1008236
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AT richardsaffery humanplacentalmethylomeintheinterplayofadverseplacentalhealthenvironmentalexposureandpregnancyoutcome
AT borisnovakovic humanplacentalmethylomeintheinterplayofadverseplacentalhealthenvironmentalexposureandpregnancyoutcome
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