Integrating Interleukin-6 into depression diagnosis and treatment

Integrating Interleukin-6 into depression diagnosis and treatment

There is growing evidence of a relationship between inflammation and psychiatric illness. In particular, the cytokine Interleukin-6 (IL-6) has been linked to stress-related disorders such as depression and anxiety. Here we discuss evidence from preclinical and clinical studies examining the role of...

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Main Authors: Georgia E. Hodes, Caroline Ménard, Scott J. Russo
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Neurobiology of Stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289515300461
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spelling doaj-fe320440948e4edb93ebfe08dcb8b8712020-11-24T23:01:07ZengElsevierNeurobiology of Stress2352-28952016-10-014C152210.1016/j.ynstr.2016.03.003Integrating Interleukin-6 into depression diagnosis and treatmentGeorgia E. HodesCaroline MénardScott J. RussoThere is growing evidence of a relationship between inflammation and psychiatric illness. In particular, the cytokine Interleukin-6 (IL-6) has been linked to stress-related disorders such as depression and anxiety. Here we discuss evidence from preclinical and clinical studies examining the role of IL-6 in mood disorders. We focus on the functional role of peripheral and central release of IL-6 on the development of stress susceptibility and depression-associated behavior. By examining the contribution of both peripheral and central IL-6 to manifestations of stress-related symptomatology, we hope to broaden the way the field thinks about diagnosing and treating mood disorders.http://www.sciencedirect.com/science/article/pii/S2352289515300461
collection DOAJ
language English
format Article
sources DOAJ
author Georgia E. Hodes
Caroline Ménard
Scott J. Russo
spellingShingle Georgia E. Hodes
Caroline Ménard
Scott J. Russo
Integrating Interleukin-6 into depression diagnosis and treatment
Neurobiology of Stress
author_facet Georgia E. Hodes
Caroline Ménard
Scott J. Russo
author_sort Georgia E. Hodes
title Integrating Interleukin-6 into depression diagnosis and treatment
title_short Integrating Interleukin-6 into depression diagnosis and treatment
title_full Integrating Interleukin-6 into depression diagnosis and treatment
title_fullStr Integrating Interleukin-6 into depression diagnosis and treatment
title_full_unstemmed Integrating Interleukin-6 into depression diagnosis and treatment
title_sort integrating interleukin-6 into depression diagnosis and treatment
publisher Elsevier
series Neurobiology of Stress
issn 2352-2895
publishDate 2016-10-01
description There is growing evidence of a relationship between inflammation and psychiatric illness. In particular, the cytokine Interleukin-6 (IL-6) has been linked to stress-related disorders such as depression and anxiety. Here we discuss evidence from preclinical and clinical studies examining the role of IL-6 in mood disorders. We focus on the functional role of peripheral and central release of IL-6 on the development of stress susceptibility and depression-associated behavior. By examining the contribution of both peripheral and central IL-6 to manifestations of stress-related symptomatology, we hope to broaden the way the field thinks about diagnosing and treating mood disorders.
url http://www.sciencedirect.com/science/article/pii/S2352289515300461
work_keys_str_mv AT georgiaehodes integratinginterleukin6intodepressiondiagnosisandtreatment
AT carolinemenard integratinginterleukin6intodepressiondiagnosisandtreatment
AT scottjrusso integratinginterleukin6intodepressiondiagnosisandtreatment
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