Use of Generalized Additive Model to Detect the Threshold of δ-Aminolevulinic Acid Dehydratase Activity Reduced by Lead Exposure

Use of Generalized Additive Model to Detect the Threshold of δ-Aminolevulinic Acid Dehydratase Activity Reduced by Lead Exposure

Background: Lead inhibits the enzymes in heme biosynthesis, mainly reducing δ-aminolevulinic acid dehydratase (ALAD) activity, which could be an available biomarker. The aim of this study was to detect the threshold of δ-aminolevulinic acid dehydratase activity reduced by lead exposure. Methods: We...

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Bibliographic Details
Main Authors: Chan-Ching Huang, Chen-Cheng Yang, Te-Yu Liu, Chia-Yen Dai, Chao-Ling Wang, Hung-Yi Chuang
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Environmental Research and Public Health
Subjects:
generalized additive model (GAM)
blood lead
delta-aminolevulinic dehydratase (ALAD)
ALAD polymorphism
hemopoietic enzyme
Online Access:https://www.mdpi.com/1660-4601/17/16/5712

Internet

https://www.mdpi.com/1660-4601/17/16/5712

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