Identification of four insertion sites for foreign genes in a pseudorabies virus vector

Identification of four insertion sites for foreign genes in a pseudorabies virus vector

Abstract Background Pseudorabies virus (PRV) is a preferred vector for recombinant vaccine construction. Previously, we generated a TK&gE-deleted PRV (PRVΔ TK&gE−AH02) based on a virulent PRV AH02LA strain. It was shown to be safe for 1-day-old piglets with maternal PRV antibodies and 4 ~ 5...

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Bibliographic Details
Main Authors: Chuanjian Zhang, Shiqi Guo, Rongli Guo, Saisai Chen, Yating Zheng, Mengwei Xu, Zhisheng Wang, Yamei Liu, Jichun Wang
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Veterinary Research
Subjects:
Pseudorabies virus
Bacterial artificial chromosome
Noncoding region
Insertion site
Spike gene
Online Access:https://doi.org/10.1186/s12917-021-02887-w

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