Amyloidogenic propensity of a natural variant of human apolipoprotein A-I: stability and interaction with ligands.

Amyloidogenic propensity of a natural variant of human apolipoprotein A-I: stability and interaction with ligands.

A number of naturally occurring mutations of human apolipoprotein A-I (apoA-I) have been associated with hereditary amyloidoses. The molecular mechanisms involved in amyloid-associated pathology remain largely unknown. Here we examined the effects of the Arg173Pro point mutation in apoA-I on the str...

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Bibliographic Details
Main Authors: Silvana A Rosú, Omar J Rimoldi, Eduardo D Prieto, Lucrecia M Curto, José M Delfino, Nahuel A Ramella, M Alejandra Tricerri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4423886?pdf=render

Internet

http://europepmc.org/articles/PMC4423886?pdf=render

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