DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection

DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection

As pattern recognition receptors, cytosolic DNA sensors quickly induce an effective innate immune response. Poxvirus, a large DNA virus, is capable of evading the host antiviral innate immune response. In this review, we summarize the latest studies on how poxvirus is sensed by the host innate immun...

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Bibliographic Details
Main Authors: Yue Lu, Leiliang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
poxvirus
cGAS
DNA-PK
IFI16
STING
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01637/full
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spelling doaj-fdf07b2415f24c7097b7d005b3744fc02020-11-25T03:56:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-08-011110.3389/fimmu.2020.01637552225DNA-Sensing Antiviral Innate Immunity in Poxvirus InfectionYue Lu0Yue Lu1Yue Lu2Yue Lu3Leiliang Zhang4Leiliang Zhang5Leiliang Zhang6Leiliang Zhang7Leiliang Zhang8Department of Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, ChinaInstitute of Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaKey Laboratory for Biotech-Drugs of National Health Commission, Jinan, ChinaKey Laboratory for Rare and Uncommon Diseases of Shandong Province, Jinan, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, ChinaInstitute of Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaKey Laboratory for Biotech-Drugs of National Health Commission, Jinan, ChinaKey Laboratory for Rare and Uncommon Diseases of Shandong Province, Jinan, ChinaScience and Technology Innovation Center, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, ChinaAs pattern recognition receptors, cytosolic DNA sensors quickly induce an effective innate immune response. Poxvirus, a large DNA virus, is capable of evading the host antiviral innate immune response. In this review, we summarize the latest studies on how poxvirus is sensed by the host innate immune system and how poxvirus-encoded proteins antagonize DNA sensors. A comprehensive understanding of the interplay between poxvirus and DNA-sensing antiviral immune responses of the host will contribute to the development of new antiviral therapies and vaccines in the future.https://www.frontiersin.org/article/10.3389/fimmu.2020.01637/fullpoxviruscGASDNA-PKIFI16STING
collection DOAJ
language English
format Article
sources DOAJ
author Yue Lu
Yue Lu
Yue Lu
Yue Lu
Leiliang Zhang
Leiliang Zhang
Leiliang Zhang
Leiliang Zhang
Leiliang Zhang
spellingShingle Yue Lu
Yue Lu
Yue Lu
Yue Lu
Leiliang Zhang
Leiliang Zhang
Leiliang Zhang
Leiliang Zhang
Leiliang Zhang
DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection
Frontiers in Immunology
poxvirus
cGAS
DNA-PK
IFI16
STING
author_facet Yue Lu
Yue Lu
Yue Lu
Yue Lu
Leiliang Zhang
Leiliang Zhang
Leiliang Zhang
Leiliang Zhang
Leiliang Zhang
author_sort Yue Lu
title DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection
title_short DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection
title_full DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection
title_fullStr DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection
title_full_unstemmed DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection
title_sort dna-sensing antiviral innate immunity in poxvirus infection
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2020-08-01
description As pattern recognition receptors, cytosolic DNA sensors quickly induce an effective innate immune response. Poxvirus, a large DNA virus, is capable of evading the host antiviral innate immune response. In this review, we summarize the latest studies on how poxvirus is sensed by the host innate immune system and how poxvirus-encoded proteins antagonize DNA sensors. A comprehensive understanding of the interplay between poxvirus and DNA-sensing antiviral immune responses of the host will contribute to the development of new antiviral therapies and vaccines in the future.
topic poxvirus
cGAS
DNA-PK
IFI16
STING
url https://www.frontiersin.org/article/10.3389/fimmu.2020.01637/full
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