The effect of genetically modified platelet-derived growth factor-BB over-expressing mesenchymal stromal cells during core decompression for steroid-associated osteonecrosis of the femoral head in rabbits

The effect of genetically modified platelet-derived growth factor-BB over-expressing mesenchymal stromal cells during core decompression for steroid-associated osteonecrosis of the femoral head in rabbits

Abstract Background Approximately one third of patients undergoing core decompression (CD) for early-stage osteonecrosis of the femoral head (ONFH) experience progression of the disease, and subsequently require total hip arthroplasty (THA). Thus, identifying adjunctive treatments to optimize bone r...

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Bibliographic Details
Main Authors: Roberto Alfonso Guzman, Masahiro Maruyama, Seyedsina Moeinzadeh, Elaine Lui, Ning Zhang, Hunter W. Storaci, Kaysie Tam, Elijah Ejun Huang, Takeshi Utsunomiya, Claire Rhee, Qi Gao, Zhenyu Yao, Yunzhi Peter Yang, Stuart B. Goodman
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Stem Cell Research & Therapy
Subjects:
Osteonecrosis
Core decompression
Femoral head
Hip
Regenerative medicine
Rabbit
Online Access:https://doi.org/10.1186/s13287-021-02572-7

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