The ever-expanding immunomodulatory role of calreticulin in cancer immunity

The ever-expanding immunomodulatory role of calreticulin in cancer immunity

Calreticulin is a pleiotropic molecule that normally resides in the lumen of the endoplasmatic reticulum (ER). Here it has various functions, ranging from regulation of calcium homeostasis to ensuring proper protein folding. More recently, calreticulin gained especial interest for its extracellular...

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Bibliographic Details
Main Authors: Marco ede Bruyn, Valerie Rose Wiersma, Wijnand eHelfrich, Paul eEggleton, Edwin eBremer
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Oncology
Subjects:
Calreticulin
Immunomodulation
TNF
Immunogenic cell death
Complex formation
Tumor necrosis factor related apoptosis inducing ligand
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00035/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00035/full

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