Single-molecule functional anatomy of endogenous HER2-HER3 heterodimers

Single-molecule functional anatomy of endogenous HER2-HER3 heterodimers

Human epidermal growth factor receptors (HERs) are the primary targets of many directed cancer therapies. However, the reason a specific dimer of HERs generates a stronger proliferative signal than other permutations remains unclear. Here, we used single-molecule immunoprecipitation to develop a bio...

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Bibliographic Details
Main Authors: Byoungsan Choi, Minkwon Cha, Gee Sung Eun, Dae Hee Lee, Seul Lee, Muhammad Ehsan, Pil Seok Chae, Won Do Heo, YongKeun Park, Tae-Young Yoon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
receptor tyrosine kinase
protein interaction
tyrosine phosphorylation
catalytic rate
Online Access:https://elifesciences.org/articles/53934

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