Chemoselective reduction of aldehydes by ruthenium trichloride and resin-bound formates

Chemoselective reduction of aldehydes by ruthenium trichloride and resin-bound formates

A simple, chemoselective transfer hydrogenation of aryl aldehydes with the aid of Amberlite® resin formate (ARF), a stable H-donor, in the presence of catalytic ruthenium trichloride is described. Aromatic aldehydes and 1,2-diketones are reduced efficiently and selectively, while aryl ketones remain...

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Bibliographic Details
Main Authors: Basudeb Basu, Bablee Mandal, Sajal Das, Pralay Das, Ashis K. Nanda
Format: Article
Language:English
Published: Beilstein-Institut 2008-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Amberlite® resins
chemoselectivity
hydrogen transfer
reduction of carbonyl group
ruthenium chloride
Online Access:https://doi.org/10.3762/bjoc.4.53
Description
Summary:A simple, chemoselective transfer hydrogenation of aryl aldehydes with the aid of Amberlite® resin formate (ARF), a stable H-donor, in the presence of catalytic ruthenium trichloride is described. Aromatic aldehydes and 1,2-diketones are reduced efficiently and selectively, while aryl ketones remain unchanged. Several other potentially reducible groups attached to the aromatic moiety are unaffected.
ISSN:1860-5397

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