Differential pulse anodic stripping voltammetric determination of berberine using nano-Na-montmorillonite clay modifiedcarbon paste electrode

• Main Authors: Chen Wen, Zhang Ming-Xiao, Li Cong, Li Yong-Ling
• Format: Article
• Language: English
• Published: Serbian Chemical Society 2013-01-01
• Series: Journal of the Serbian Chemical Society
• Subjects: berberine; nano-Na-montmorillonite clay; carbon paste electrode; modified electrode; electrochemical determination
• Online Access: http://www.doiserbia.nb.rs/img/doi/0352-5139/2013/0352-51391200093C.pdf

A simple and sensitive method was presented to electrochemical determination of berberine based on the nano-Na-montmorillonite (nano-Na-MMT) clay modified carbon paste electrode. The electrochemical oxidation and adsorption behavior of berberine was studied at the proposed electrodeby linear sweep voltammetry in acetate buffer (0.2 M, pH 5.6). A differential pulse anodic stripping voltammetric procedure has been developed fordetermination of the drug. A good linear relationship between the oxidation peak current magnitude and the concentration of berberine was observed in the range from 1.0 to 18.0 µgmL-1with detection limit of 0.07 µgmL-1and quantitation limit of0.24 µgmL-1. The proposed method was successfully applied to the determination of berberine in pharmaceutical tablets.