Emerging roles of chromatin in the maintenance of genome organization and function in plants

Emerging roles of chromatin in the maintenance of genome organization and function in plants

Abstract Chromatin is not a uniform macromolecular entity; it contains different domains characterized by complex signatures of DNA and histone modifications. Such domains are organized both at a linear scale along the genome and spatially within the nucleus. We discuss recent discoveries regarding...

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Main Authors: Zaida Vergara, Crisanto Gutierrez
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Genome Biology
Online Access:http://link.springer.com/article/10.1186/s13059-017-1236-9
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spelling doaj-fdc2f36d6b4b424eabb9bdbfa63c7a5d2020-11-25T00:41:11ZengBMCGenome Biology1474-760X2017-05-0118111210.1186/s13059-017-1236-9Emerging roles of chromatin in the maintenance of genome organization and function in plantsZaida Vergara0Crisanto Gutierrez1Centro de Biología Molecular Severo Ochoa, CSIC-UAMCentro de Biología Molecular Severo Ochoa, CSIC-UAMAbstract Chromatin is not a uniform macromolecular entity; it contains different domains characterized by complex signatures of DNA and histone modifications. Such domains are organized both at a linear scale along the genome and spatially within the nucleus. We discuss recent discoveries regarding mechanisms that establish boundaries between chromatin states and nuclear territories. Chromatin organization is crucial for genome replication, transcriptional silencing, and DNA repair and recombination. The replication machinery is relevant for the maintenance of chromatin states, influencing DNA replication origin specification and accessibility. Current studies reinforce the idea of intimate crosstalk between chromatin features and processes involving DNA transactions.http://link.springer.com/article/10.1186/s13059-017-1236-9
collection DOAJ
language English
format Article
sources DOAJ
author Zaida Vergara
Crisanto Gutierrez
spellingShingle Zaida Vergara
Crisanto Gutierrez
Emerging roles of chromatin in the maintenance of genome organization and function in plants
Genome Biology
author_facet Zaida Vergara
Crisanto Gutierrez
author_sort Zaida Vergara
title Emerging roles of chromatin in the maintenance of genome organization and function in plants
title_short Emerging roles of chromatin in the maintenance of genome organization and function in plants
title_full Emerging roles of chromatin in the maintenance of genome organization and function in plants
title_fullStr Emerging roles of chromatin in the maintenance of genome organization and function in plants
title_full_unstemmed Emerging roles of chromatin in the maintenance of genome organization and function in plants
title_sort emerging roles of chromatin in the maintenance of genome organization and function in plants
publisher BMC
series Genome Biology
issn 1474-760X
publishDate 2017-05-01
description Abstract Chromatin is not a uniform macromolecular entity; it contains different domains characterized by complex signatures of DNA and histone modifications. Such domains are organized both at a linear scale along the genome and spatially within the nucleus. We discuss recent discoveries regarding mechanisms that establish boundaries between chromatin states and nuclear territories. Chromatin organization is crucial for genome replication, transcriptional silencing, and DNA repair and recombination. The replication machinery is relevant for the maintenance of chromatin states, influencing DNA replication origin specification and accessibility. Current studies reinforce the idea of intimate crosstalk between chromatin features and processes involving DNA transactions.
url http://link.springer.com/article/10.1186/s13059-017-1236-9
work_keys_str_mv AT zaidavergara emergingrolesofchromatininthemaintenanceofgenomeorganizationandfunctioninplants
AT crisantogutierrez emergingrolesofchromatininthemaintenanceofgenomeorganizationandfunctioninplants
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