ARHGAP21 Acts as an Inhibitor of the Glucose-Stimulated Insulin Secretion Process

ARHGAP21 Acts as an Inhibitor of the Glucose-Stimulated Insulin Secretion Process

ARHGAP21 is a RhoGAP protein implicated in the modulation of insulin secretion and energy metabolism. ARHGAP21 transient-inhibition increase glucose-stimulated insulin secretion (GSIS) in neonatal islets; however, ARHGAP21 heterozygote mice have a reduced insulin secretion. These discrepancies are n...

Full description

Bibliographic Details
Main Authors: Sandra M. Ferreira, José M. Costa-Júnior, Mirian A. Kurauti, Nayara C. Leite, Fernanda Ortis, Luiz F. Rezende, Helena C. Barbosa, Antonio C. Boschero, Gustavo J. Santos
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Endocrinology
Subjects:
ARHGAP21
insulin secretion
calcium influx
type 2 diabetes
Ob/Ob mice
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.599165/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2020.599165/full

Similar Items