Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector

Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector

Mutations in the melanocortin-4-receptor (MC4R) comprise the most common monogenic form of severe early-onset obesity, and conventional treatments are either ineffective long-term or contraindicated. Immediately downstream of MC4R—in the pathway for regulating energy balance—is brain-derived neurotr...

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Bibliographic Details
Main Authors: Jason J. Siu, Nicholas J. Queen, Xianglan Liu, Wei Huang, Travis McMurphy, Lei Cao
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
BDNF
melanocortin-4 receptor
gene therapy
obesity
metabolic syndrome
AAV
hypothalamus
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117301043

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