Reduction in BDNF from Inefficient Precursor Conversion Influences Nest Building and Promotes Depressive-Like Behavior in Mice

Reduction in BDNF from Inefficient Precursor Conversion Influences Nest Building and Promotes Depressive-Like Behavior in Mice

We generated a knock-in mouse line in which the gene encoding brain-derived neurotrophic factor (<i>Bdnf</i>)<i> </i>was replaced with a sequence for proBDNF containing human single nucleotide polymorphisms encoding arginines proximal to the cleavage site (R125M and R127L). T...

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Bibliographic Details
Main Authors: Masami Kojima, Hikari Otabi, Haruko Kumanogoh, Atsushi Toyoda, Masahito Ikawa, Masaru Okabe, Toshiyuki Mizui
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
BDNF
depression
nest building
cleavage
SNP
social isolation
Online Access:https://www.mdpi.com/1422-0067/21/11/3984

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