Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91<sup><it>phox </it></sup>subunit of NADPH oxidase

Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91<sup><it>phox </it></sup>subunit of NADPH oxidase

<p>Abstract</p> <p>Background</p> <p>Both (-) and (+)-naloxone attenuate inflammation-mediated neurodegeneration by inhibition of microglial activation through superoxide reduction in an opioid receptor-independent manner. Multiple lines of evidence have documented a pi...

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Bibliographic Details
Main Authors: Wang Qingshan, Zhou Hui, Gao Huiming, Chen Shih-Heng, Chu Chun-Hsien, Wilson Belinda, Hong Jau-Shyong
Format: Article
Language:English
Published: BMC 2012-02-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Microglia
NADPH oxidase
Opioid receptor
Binding
Online Access:http://www.jneuroinflammation.com/content/9/1/32

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