In Silico Study of the Mechanism of Binding of the N-Terminal Region of α Synuclein to Synaptic-Like Membranes

In Silico Study of the Mechanism of Binding of the N-Terminal Region of α Synuclein to Synaptic-Like Membranes

The membrane binding by α-synuclein (αS), a presynaptic protein whose aggregation is strongly linked with Parkinson’s disease, influences its biological behavior under functional and pathological conditions. This interaction requires a conformational transition from a disordered-unbound to a partial...

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Bibliographic Details
Main Authors: Carlos Navarro-Paya, Maximo Sanz-Hernandez, Alfonso De Simone
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Life
Subjects:
α-Synuclein
membrane binding
disorder-to-order transition
coarse-grained simulations
Parkinson’s disease
Online Access:https://www.mdpi.com/2075-1729/10/6/98

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