A discrepancy between clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitis

A discrepancy between clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitis

We report the case of a 64-year old man who presented memory disturbance, low-grade fever, weight loss, and bilateral hand tremors for three months. He was diagnosed with non-herpetic acute limbic encephalitis (NHALE). Follow-up magnetic resonance imaging (MRI) revealed new lesions after symptomatic...

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Main Authors: Naoto Kohno, Yuko Kawakami, Chizuko Hamada, Genya Toyoda, Hirokazu Bokura, Shuhei Yamaguchi, Yukitoshi Takahashi
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Neurology International
Subjects:
non-herpetic acute limbic encephalitis, steroid pulse therapy, magnetic resonance imaging, autoantibodies against glutamate receptors epsilon 2 and delta 2
Online Access:http://www.pagepress.org/journals/index.php/ni/article/view/4266
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spelling doaj-fd8ad95b0cdf40628f66aa24784abc142021-01-02T13:32:34ZengMDPI AGNeurology International2035-83852035-83772013-06-0152e8e810.4081/ni.2013.e82513A discrepancy between clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitisNaoto Kohno0Yuko Kawakami1Chizuko Hamada2Genya Toyoda3Hirokazu Bokura4Shuhei Yamaguchi5Yukitoshi Takahashi6Department of Neurology, Ohda Municipal Hospital, OhdaDepartment of Neurology, Shimane Prefectural Central Hospital, IzumoDepartment of Neurology, Shimane Prefectural Central Hospital, IzumoDepartment of Neurology, Shimane Prefectural Central Hospital, IzumoDepartment of Neurology, Shimane Prefectural Central Hospital, IzumoDepartment of Neurology, Faculty of Medicine, Shimane University, ShimaneDepartment of Research Shizuoka, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, ShizuokaWe report the case of a 64-year old man who presented memory disturbance, low-grade fever, weight loss, and bilateral hand tremors for three months. He was diagnosed with non-herpetic acute limbic encephalitis (NHALE). Follow-up magnetic resonance imaging (MRI) revealed new lesions after symptomatic improvement following steroid pulse therapy. This may indicate that there is a time lag between the disturbance or recovery of neurons and astrocytes. Thus, other lesions might occasionally appear during convalescence in patients with NHALE, even if only minimal lesions were found on the initial MRI.http://www.pagepress.org/journals/index.php/ni/article/view/4266non-herpetic acute limbic encephalitis, steroid pulse therapy, magnetic resonance imaging, autoantibodies against glutamate receptors epsilon 2 and delta 2
collection DOAJ
language English
format Article
sources DOAJ
author Naoto Kohno
Yuko Kawakami
Chizuko Hamada
Genya Toyoda
Hirokazu Bokura
Shuhei Yamaguchi
Yukitoshi Takahashi
spellingShingle Naoto Kohno
Yuko Kawakami
Chizuko Hamada
Genya Toyoda
Hirokazu Bokura
Shuhei Yamaguchi
Yukitoshi Takahashi
A discrepancy between clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitis
Neurology International
non-herpetic acute limbic encephalitis, steroid pulse therapy, magnetic resonance imaging, autoantibodies against glutamate receptors epsilon 2 and delta 2
author_facet Naoto Kohno
Yuko Kawakami
Chizuko Hamada
Genya Toyoda
Hirokazu Bokura
Shuhei Yamaguchi
Yukitoshi Takahashi
author_sort Naoto Kohno
title A discrepancy between clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitis
title_short A discrepancy between clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitis
title_full A discrepancy between clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitis
title_fullStr A discrepancy between clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitis
title_full_unstemmed A discrepancy between clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitis
title_sort discrepancy between clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitis
publisher MDPI AG
series Neurology International
issn 2035-8385
2035-8377
publishDate 2013-06-01
description We report the case of a 64-year old man who presented memory disturbance, low-grade fever, weight loss, and bilateral hand tremors for three months. He was diagnosed with non-herpetic acute limbic encephalitis (NHALE). Follow-up magnetic resonance imaging (MRI) revealed new lesions after symptomatic improvement following steroid pulse therapy. This may indicate that there is a time lag between the disturbance or recovery of neurons and astrocytes. Thus, other lesions might occasionally appear during convalescence in patients with NHALE, even if only minimal lesions were found on the initial MRI.
topic non-herpetic acute limbic encephalitis, steroid pulse therapy, magnetic resonance imaging, autoantibodies against glutamate receptors epsilon 2 and delta 2
url http://www.pagepress.org/journals/index.php/ni/article/view/4266
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