RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling

RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling

Invading pathogen nucleic acids are recognized and bound by cytoplasmic (retinoic acid-inducible gene I [RIG-I]-like) and membrane-bound (Toll-like) pattern recognition receptors to activate innate immune signaling. Modified nucleotides, when present in RNA molecules, diminish the magnitude of these...

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Bibliographic Details
Main Authors:	Ann Fiegen Durbin, Chen Wang, Joseph Marcotrigiano, Lee Gehrke
Format:	Article
Language:	English
Published:	American Society for Microbiology 2016-09-01
Series:	mBio
Online Access:	http://mbio.asm.org/cgi/content/full/7/5/e00833-16

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