Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca2+channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-independent calcium influx and catecholamine secretion.
Bibliographic Details
| Main Authors: |
Chun-Hua Liu,
Zheng Gong,
Zong-Lai Liang,
Zhi-Xin Liu,
Fan Yang,
Yu-Jing Sun,
Ming-Liang Ma,
Yi-Jing Wang,
Chao-Ran Ji,
Yu-Hong Wang,
Mei-Jie Wang,
Fu-Ai Cui,
Amy Lin,
Wen-Shuai Zheng,
Dong-Fang He,
Chang-xiu Qu,
Peng Xiao,
Chuan-Yong Liu,
Alex R. B. Thomsen,
Thomas Joseph Cahill,
Alem W. Kahsai,
Fan Yi,
Kun-Hong Xiao,
Tian Xue,
Zhuan Zhou,
Xiao Yu,
Jin-Peng Sun |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms14335
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