A rare case of Castleman's disease presenting as a pulmonary mass mimicking pulmonary malignancy

<p>Castleman disease is a rare disorder of the lymphoid system characterized by noncancerous growths that may develop in lymph node tissues throughout the body. Most often this occurs in the neck, mediastinum, and abdomen where lymph nodes aggregate. The etiology is thought to be due to antige...

Full description

Bibliographic Details
Main Authors: R Bashyal, MC Lee, B Thakur, LN Singh
Format: Article
Language:English
Published: Association of Clinical Pathologists of Nepal 2011-03-01
Series:Journal of Pathology of Nepal
Subjects:
Online Access:http://www.nepjol.info/index.php/JPN/article/view/4456
id doaj-fd760390c99044b7975215df3733ca03
record_format Article
spelling doaj-fd760390c99044b7975215df3733ca032020-11-25T01:12:21ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082011-03-0111636510.3126/jpn.v1i1.44563694A rare case of Castleman's disease presenting as a pulmonary mass mimicking pulmonary malignancyR Bashyal0MC Lee1B Thakur2LN Singh3Department of Pathology, BP Koirala Memorial Cancer Hospital, BharatpurDepartment of Pathology, BP Koirala Memorial Cancer Hospital, BharatpurDepartment of Surgery, BP Koirala Memorial Cancer Hospital, BharatpurDepartment of Radiology, BP Koirala Memorial Cancer Hospital, Bharatpur<p>Castleman disease is a rare disorder of the lymphoid system characterized by noncancerous growths that may develop in lymph node tissues throughout the body. Most often this occurs in the neck, mediastinum, and abdomen where lymph nodes aggregate. The etiology is thought to be due to antigenic hyperstimulation of unknown origin. Two histological subtypes are described with different clinical presentations and therapeutic implications. Diagnosis is frequently accomplished only by histological analysis after surgery since no specific features have been found in imaging studies. Surgical excision is both diagnostic and curative in localized forms, whereas additional therapies are required in multicentric forms. Here we describe a case of castleman disease adjacent to the right pulmonary hilum loosely adherent to the interlobar branch of the right pulmonary artery that mimicked tuberculosis or malignancy in a 30-year-old man who underwent curative surgical removal of the mass.<strong> </strong></p> <p><strong>Keywords: </strong>Castleman disease; Pulmonary malignancy; IL-6; HHV-8; Kaposi sarcoma</p> <p>DOI: 10.3126/jpn.v1i1.4456</p> <p><em>Journal of Pathology of Nepal </em>(2011) Vol.1, 63-65</p>http://www.nepjol.info/index.php/JPN/article/view/4456Castleman diseasePulmonary malignancyIL-6HHV-8Kaposi sarcoma
collection DOAJ
language English
format Article
sources DOAJ
author R Bashyal
MC Lee
B Thakur
LN Singh
spellingShingle R Bashyal
MC Lee
B Thakur
LN Singh
A rare case of Castleman's disease presenting as a pulmonary mass mimicking pulmonary malignancy
Journal of Pathology of Nepal
Castleman disease
Pulmonary malignancy
IL-6
HHV-8
Kaposi sarcoma
author_facet R Bashyal
MC Lee
B Thakur
LN Singh
author_sort R Bashyal
title A rare case of Castleman's disease presenting as a pulmonary mass mimicking pulmonary malignancy
title_short A rare case of Castleman's disease presenting as a pulmonary mass mimicking pulmonary malignancy
title_full A rare case of Castleman's disease presenting as a pulmonary mass mimicking pulmonary malignancy
title_fullStr A rare case of Castleman's disease presenting as a pulmonary mass mimicking pulmonary malignancy
title_full_unstemmed A rare case of Castleman's disease presenting as a pulmonary mass mimicking pulmonary malignancy
title_sort rare case of castleman's disease presenting as a pulmonary mass mimicking pulmonary malignancy
publisher Association of Clinical Pathologists of Nepal
series Journal of Pathology of Nepal
issn 2091-0797
2091-0908
publishDate 2011-03-01
description <p>Castleman disease is a rare disorder of the lymphoid system characterized by noncancerous growths that may develop in lymph node tissues throughout the body. Most often this occurs in the neck, mediastinum, and abdomen where lymph nodes aggregate. The etiology is thought to be due to antigenic hyperstimulation of unknown origin. Two histological subtypes are described with different clinical presentations and therapeutic implications. Diagnosis is frequently accomplished only by histological analysis after surgery since no specific features have been found in imaging studies. Surgical excision is both diagnostic and curative in localized forms, whereas additional therapies are required in multicentric forms. Here we describe a case of castleman disease adjacent to the right pulmonary hilum loosely adherent to the interlobar branch of the right pulmonary artery that mimicked tuberculosis or malignancy in a 30-year-old man who underwent curative surgical removal of the mass.<strong> </strong></p> <p><strong>Keywords: </strong>Castleman disease; Pulmonary malignancy; IL-6; HHV-8; Kaposi sarcoma</p> <p>DOI: 10.3126/jpn.v1i1.4456</p> <p><em>Journal of Pathology of Nepal </em>(2011) Vol.1, 63-65</p>
topic Castleman disease
Pulmonary malignancy
IL-6
HHV-8
Kaposi sarcoma
url http://www.nepjol.info/index.php/JPN/article/view/4456
work_keys_str_mv AT rbashyal ararecaseofcastlemansdiseasepresentingasapulmonarymassmimickingpulmonarymalignancy
AT mclee ararecaseofcastlemansdiseasepresentingasapulmonarymassmimickingpulmonarymalignancy
AT bthakur ararecaseofcastlemansdiseasepresentingasapulmonarymassmimickingpulmonarymalignancy
AT lnsingh ararecaseofcastlemansdiseasepresentingasapulmonarymassmimickingpulmonarymalignancy
AT rbashyal rarecaseofcastlemansdiseasepresentingasapulmonarymassmimickingpulmonarymalignancy
AT mclee rarecaseofcastlemansdiseasepresentingasapulmonarymassmimickingpulmonarymalignancy
AT bthakur rarecaseofcastlemansdiseasepresentingasapulmonarymassmimickingpulmonarymalignancy
AT lnsingh rarecaseofcastlemansdiseasepresentingasapulmonarymassmimickingpulmonarymalignancy
_version_ 1725166963415580672