A simple and efficient approach to the synthesis of 2-substituted benzimidazole via sp3 C–H functionalization

A simple and efficient approach to the synthesis of 2-substituted benzimidazole via sp3 C–H functionalization

A facile and novel approach to the synthesis of 2-substituted benzimidazole was developed via a tandem reaction following sp3 C–H functionalization. Here we report a simple, efficient and tandem oxidative dehydrative coupling reaction of N-benzylbezene-1,2-diamine in the presence of oxidant tert-but...

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Bibliographic Details
Main Authors: Sachin V. Patil, Sachin S. Patil, Vivek D. Bobade
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Arabian Journal of Chemistry
Subjects:
2-Substituted benzimidazole
Tandem reaction
CDC (cross dehydrative coupling)
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535211001699
Description
Summary:A facile and novel approach to the synthesis of 2-substituted benzimidazole was developed via a tandem reaction following sp3 C–H functionalization. Here we report a simple, efficient and tandem oxidative dehydrative coupling reaction of N-benzylbezene-1,2-diamine in the presence of oxidant tert-butyl hydroperoxide (TBHP) in solvent acetonitrile to give substituted benzimidazole.
ISSN:1878-5352

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