Endogenous T Cell Receptor Rearrangement Represses Aggressive Central Nervous System Autoimmunity in a TcR-Transgenic Model on the Non-Obese Diabetic Background

Endogenous T Cell Receptor Rearrangement Represses Aggressive Central Nervous System Autoimmunity in a TcR-Transgenic Model on the Non-Obese Diabetic Background

The T cell response to central nervous system (CNS) antigen in experimental autoimmune encephalomyelitis (EAE) permits one to model the immune aspects of multiple sclerosis. 1C6 transgenic mice on the non-obese diabetic (NOD) background possess a class II-restricted T cell receptor (TcR; Vα5-Vβ7) sp...

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Bibliographic Details
Main Authors: Asmita Pradeep Yeola, Prenitha Mercy Ignatius Arokia Doss, Joanie Baillargeon, Irshad Akbar, Benoit Mailhot, Mohammad Balood, Sébastien Talbot, Ana Carrizosa Anderson, Steve Lacroix, Manu Rangachari
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
EAE (experimental autoimmune encephalomyelitis)
1C6
TCR transgenic mice
Treg—regulatory T cell
non-obese diabetic (NOD)
allelic exclusion
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03115/full

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