Serum Omentin-1 as a Disease Activity Marker for Crohn’s Disease

• Main Authors: Yan Lu, Li Zhou, Lifeng Liu, Yan Feng, Li Lu, Xiaoyan Ren, Xinqian Dong, Weiwei Sang
• Format: Article
• Language: English
• Published: Hindawi Limited 2014-01-01
• Series: Disease Markers
• Online Access: http://dx.doi.org/10.1155/2014/162517
• ISSN: 0278-0240; 1875-8630

Background and Aim. It remains challenging to determine the inflammatory activity in Crohn’s disease (CD) for lack of specific laboratory markers. Recent studies suggest that serum omentin-1 is associated with inflammatory response. We aimed to assess the potential of serum omentin-1 as a marker of disease activity in CD patients. Methods. Serum omentin-1 concentrations were determined by enzyme-linked immunosorbent assay (ELISA) in patients with CD (n=240), functional gastrointestinal disorders (FGDs, n=120), and healthy controls (HC, n=60) and evaluated for correlation with disease activity. Expression of omentin-1 in colonic tissues from patients with CD was also analyzed by real-time PCR and Western blotting. Serum omentin-1 levels as an activity index were evaluated using a receiver operating characteristic (ROC) curve. Results. Serum omentin-1 concentrations were significantly decreased in active CD patients compared with patients in remission, FGDs, and HC (all P<0.001). Expression of omentin-1 was decreased at mRNA and protein levels in inflamed colonic tissues in active CD than that in noninflamed colonic tissues. Serum omentin-1 levels were negatively correlated with disease activity in CD, better than C-reactive protein (CRP). Conclusion. Our results indicate that serum and colonic omentin-1 expressions are decreased in active CD patients. The correlation of serum omentin-1 with disease activity in CD is superior to that of CRP. Serum omentin-1 is a potential marker for CD disease activity.