DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling

DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling

Abstract Cardiomyocytes of newborn mice proliferate after injury or exposure to growth factors. However, these responses are diminished after postnatal day-6 (P6), representing a barrier to building new cardiac muscle in adults. We have previously shown that exogenous thyroid hormone (T3) stimulates...

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Bibliographic Details
Main Authors: Nikolay Bogush, Lin Tan, Hussain Naib, Ebrahim Faizullabhoy, John W. Calvert, Siiri E. Iismaa, Ankan Gupta, Ramani Ramchandran, David I. K. Martin, Robert M. Graham, Ahsan Husain, Nawazish Naqvi
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-78825-x

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