Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APPSWE

Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APPSWE

Amyloid deposition appears to be an early and crucial event in Alzheimer’s disease (AD). To generate animal models of AD, mice expressing full-length amyloid precursor protein (APP), with mutations linked to FAD, have been created. These animals exhibit abnormalities characteristic of AD, including...

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Bibliographic Details
Main Authors: Alena V Savonenko, Guilian M Xu, Donald L Price, David R Borchelt, Alicja L Markowska
Format: Article
Language:English
Published: Elsevier 2003-04-01
Series:Neurobiology of Disease
Subjects:
Place discrimination
Water maze
Longitudinal
Cross-sectional
Memory
β-Amyloid
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102000128

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